2022 Publications

AWAREness of diagnosis and treatment of Chronic Kidney Disease in adults with Type 2 Diabetes (AWARE-CKD in T2D)
Diabetes remains the leading contributor to the development of chronic kidney disease (CKD) and end stage kidney disease, emphasizing the urgency of identifying barriers to early diagnosis and intervention. The AWARE-CKD in T2D study described the awareness, values, and preferences of physicians (general practitioners, endocrinologists, and nephrologists) and patients on the management of chronic kidney disease in patients with type 2 diabetes (CKD in T2D). The results of the survey study highlighted opportunities for improving CKD in T2D management, such as earlier referrals to nephrologists and additional education and clarity for physicians on urinary albumin testing for assessing kidney risk. More understanding of kidney risk progression is also vital for patients.

Specialist-led diabetes registries and predictors of poor glycemic control in type 2 diabetes: Insights into the functionally refractory patient from the LMC Diabetes Registry database

Randomized comparison of initiating the fixed-ratio combination of iGlarLixi or biosimilar insulin glargine together with gliclazide in South Asian origin participants with Type 2 Diabetes: VARIATION 2 SA trial
Individuals of South Asian (SA) origin comprise nearly 2 billion people worldwide, and form the largest ethnic minority population in Canada. Higher prevalence of type 2 diabetes (T2D) among immigrants of SA origin is well documented compared to other ethnicities in Canada. Hence, therapy recommendations have included utilizing combination treatment approaches and incorporating insulin earlier in disease progression. A fixed-ratio combination (FRC) of a daily basal insulin/GLP-1 RA might be ideal for this population given the relatively high daytime carbohydrate consumption, relatively lower insulin requirements, and a cultural dislike of multiple therapies.

The VARIATION 2 SA trial compared the initiation of a FRC of insulin glargine and lixisenatide (iGlarLixi) vs insulin glargine U100 (iGlar) along with gliclazide, exclusively in people of SA origin with T2D. The initiation of iGlarLixi resulted in similar time-in-range, HbA1c, fasting plasma glucose, weight and hypoglycemia compared to the more affordable option of starting iGlar + gliclazide in SA origin adults with T2D.

Specialist-led diabetes registries and predictors of poor glycemic control in type 2 diabetes: Insights into the functionally refractory patient from the LMC Diabetes Registry database

Real-world glycaemic outcomes in adult persons with type 1 diabetes using a real-time continuous glucose monitor compared to an intermittently scanned glucose monitor: A retrospective observational study from the Canadian LMC diabetes registry (REAL-CGM-T1D)
Real-time continuous glucose monitoring (rtCGM) and intermittently scanned continuous glucose monitoring (isCGM) have both shown to improve glycemic outcomes in people with diabetes. The objective of the REAL-CGM-T1D study was to assess the real-world effectiveness of using rtCGM compared to using isCGM on HbA1c and CGM metrics in adults with type 1 diabetes (T1D). The study reported a greater reduction in HbA1c by 0.3%, higher percent time in target glucose range by 4.4%, lower percent time below target glucose range by 3.9%, and reduced glycemic variability in adults with T1D using rtCGM compared to a matched cohort of adults with T1D using isCGM. Initiating a rtCGM device compared to an isCGM device may be particularly effective when HbA1c is < 8.5% and when individuals are using multiple daily injection therapy. The findings from this retrospective study support the benefits and importance of real-time and predictive alerts for individuals with T1D. With the release of second and third generation isCGM systems that offer alerts for hypoglycemia, further investigations are warranted.

Specialist-led diabetes registries and predictors of poor glycemic control in type 2 diabetes: Insights into the functionally refractory patient from the LMC Diabetes Registry database